The most studied membrane receptor for MIF is CD74, often called HLA class II histocompatibility antigen gamma chain. in keeping with its position as a MHC course II chaperone, the highest CD74 expression is observed around the floor of antigen-presenting cells like dendritic cells, B cells, and macrophages [forty]. Upon MIF engagement, CD74 recrui

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Lung endothelial cells Screen Virtually undetectable amounts of CD74 at baseline. A recent examine observed that Serious hyperoxia resulted in CD74 upregulation in endothelial cells (seventy three). Hyperoxia is prevalent in people with adult respiratory distress syndrome (ARDS), that is as a result of prerequisite for prime levels of supplemental

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